HIV-1 inhibitor 5b ( —— )

产品货号. M17092 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

HIV-1 inhibitor 5b
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HIV-1抑制剂5b是一种新型抗HIV-1化合物，可抑制HIV-1 JR-CSF，EC50为1 nM，且无明显细胞毒性（CC50>20 uM）。
产品描述

HIV-1 inhibitor 5b is a novel anti-HIV-1 compound that inhibits HIV-1 JR-CSF with EC50 of 1 nM without significant cytotoxicity (CC50>20 uM), also shows potency against NRTI- and NNRTI-resistant HIV-1 (EC50=1-3 nM); shows a chemical backbone similar to the clinically used integrase (IN) strand transfer inhibitor (INSTI) elvitegravir, but has no detectable INSTI activity; various drug-resistant HIV-1 strains did not display cross resistance to HIV-1 inhibitor 5b; remains its anti-HIV-1 activity even after the viral integration stage, significantly suppresses p24 antigen production in HIV-1 latently infected cells exposed with TNF-alpha; demonstrates favorable pharmacokinetic profiles in mice.
体外实验

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体内实验

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同义词

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通路

Microbiology/Virology
靶点

HIV
受体

HIV
研究领域

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适应症

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CAS Number

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分子量

369.372
分子式

C20H17F2N3O2
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

1-(5-amino-2,4-difluorophenyl)-7-(3,5-dimethyl-4,5-dihydroisoxazol-4-yl)quinolin-4(1H)-one

1. Shiroishi-Wakatsuki T, et al. Antiviral Res. 2019 Feb;162:101-109.

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